|
rs4444235
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs4444235 at 14q22.2 interacted with regular exercise in colorectal cancer (p<sub>case-only</sub> = 2.4 × 10<sup>- 3</sup>, p<sub>case-control</sub> = 1.5 × 10<sup>- 3</sup>).
|
31849324 |
2019 |
|
rs895819
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that rs895819 polymorphism was correlated with increased risk of colorectal cancer and breast cancer, but not all types of cancer.
|
31838252 |
2020 |
|
rs67052019
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
An indel variant, rs67052019 at 1p13.3, was found to be associated with CRC risk at P=3.9 x 10-8 in Asians (OR per allele deletion=1.13, 95%CI=1.08-1.18).
|
31826910 |
2020 |
|
rs6687758
|
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
In conclusion, we have confirmed a CRC susceptibility locus and the existence of associations between modifiable factors and the rs6687758 SNP; moreover, the GRS was associated with CRC.
|
31821333 |
2019 |
|
rs3918242
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
|
31810917 |
2019 |
|
rs4809960
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> Our findings indicate that the <i>CYP24A1</i> rs4809960 polymorphism decreased the risk of CRC in the studied population.
|
31802707 |
2020 |
|
rs2585428
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<b>Aim:</b> rs2585428 and rs4809960 polymorphisms were significantly associated with overall cancer risk, but there is no evidence regarding the overall colorectal cancer (CRC) risk.
|
31802707 |
2020 |
|
rs590352
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.
|
31797724 |
2020 |
|
rs4796672
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.
|
31797724 |
2020 |
|
rs2072580
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of haplotypes reveals that rs2072580 of the <i>ISCU</i> and <i>SART3</i> genes can be also associated with CRC.
|
31797724 |
2020 |
|
rs2470151
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that <i>RP11-108K3.2</i> rs2470151 had a significant association with the risk of colorectal cancer; this may help to predict the susceptibility of colorectal cancer in Chinese populations.
|
31789575 |
2020 |
|
rs4809960
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results revealed that the rs4809960 and rs6022999 were strongly associated with the CRC risk, especially with the colon cancer risk.
|
31740231 |
2020 |
|
rs2585428
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, the analysis of haplotypes consisting of rs2585428(G > A), rs4809960(T > C), rs6022999(A > G) and rs6068816(C > T) indicated that haplotype ATGC significantly decreased the CRC risk, especially the colon cancer risk.
|
31740231 |
2020 |
|
rs6068816
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the analysis of haplotypes consisting of rs2585428(G > A), rs4809960(T > C), rs6022999(A > G) and rs6068816(C > T) indicated that haplotype ATGC significantly decreased the CRC risk, especially the colon cancer risk.
|
31740231 |
2020 |
|
rs6022999
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results revealed that the rs4809960 and rs6022999 were strongly associated with the CRC risk</span>, especially with the colon cancer risk.
|
31740231 |
2020 |
|
rs9939049
|
|
Colorectal Carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
The CRC susceptibility SNP rs9939049 in CDH1 influences patient survival and warrants further evaluation as a prognostic biomarker.
|
31734605 |
2020 |
|
rs8720
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Materials & methods:</b> The rs8720 and rs7960917 in <i>KRAS</i> 3'UTR for colorectal carcinoma</span> (CRC) risk and survival were investigated in a case-control study.
|
31729889 |
2020 |
|
rs7960917
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Materials & methods:</b> The rs8720 and rs7960917 in <i>KRAS</i> 3'UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case-control study.
|
31729889 |
2020 |
|
rs459552
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The haplotypes G-T in APC (rs11954856-rs459552) and A-C in DVL2 (rs2074222-rs222836) were associated with decreased risk of CRC, while the G-T haplotype in the DVL2 gene was associated with increased CRC risk.
|
31723073 |
2019 |
|
rs11954856
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The haplotypes G-T in APC (rs11954856-rs459552) and A-C in DVL2 (rs2074222-rs222836) were associated with decreased risk of CRC, while the G-T haplotype in the DVL2 gene was associated with increased CRC risk.
|
31723073 |
2019 |
|
rs9921222
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Increased susceptibility to CRC was associated with the polymorphic variants rs11954856 (APC), rs222836 (DVL2), and rs9921222 (AXIN1).
|
31723073 |
2019 |
|
rs222836
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotypes G-T in APC (rs11954856-rs459552) and A-C in DVL2 (rs2074222-rs222836) were associated with decreased risk of CRC, while the G-T haplotype in the DVL2 gene was associated with increased CRC risk.
|
31723073 |
2019 |
|
rs2074222
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotypes G-T in APC (rs11954856-rs459552) and A-C in DVL2 (rs2074222-rs222836) were associated with decreased risk of CRC, while the G-T haplotype in the DVL2 gene was associated with increased CRC risk.
|
31723073 |
2019 |
|
rs121913366
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rare BRAF L597Q mutation may be associated with aggressive tumor behavior in CRC.
|
31704811 |
2019 |
|
rs749539903
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 6 HER2-positive CRCs, <i>KRAS</i> and <i>PIK3CA</i> mutations were detected in 1 (17%; G13D) and 2 (33.3%; 1 Q546R and 1 H1047R) patients, respectively.
|
31692488 |
2019 |